Toxicology and Pharmacology

Biography

Dr. Gokul Sudhakaran is a dedicated biotechnologist and innovator whose passion for scientific exploration has propelled him to the forefront of cutting-edge research in the field of biotechnology. His insatiable thirst for knowledge led him to pursue a Bachelor's degree in Biotechnology at SRM Institute of Science and Technology in Chennai, India, where he graduated with distinction in 2018. During his undergraduate studies, Gokul undertook a research project focused on the screening and identification of plastic-degrading bacteria from a landfill site, showcasing his early interest in environmental biotechnology and sustainability. Building upon his academic foundation, Gokul pursued a Master's in Biotechnology at SRM Institute of Science and Technology, graduating with an impressive academic record in 2020. His postgraduate work involved creating a genetic repository for species identification using snake skin exuviates, highlighting his commitment to biodiversity conservation and wildlife research. In 2021, Gokul embarked on his doctoral journey at SRM Institute of Science and Technology, where he delved into groundbreaking research on the therapeutic potential of Nimbin and its derivatives in addressing various metabolic disorders. His doctoral thesis, focusing on Nimbin analogs' anti-inflammatory, antioxidant, and hepatoprotective properties, garnered widespread acclaim and recognition within the scientific community. He also received The Young Researcher Award in 2023 at the International Conference on Trends in Biological Sciences: Impetus on Human Health (ICBS); outside of academia, Gokul is an avid advocate for social causes and has actively volunteered in community projects, including teaching English and sex education in Vietnam through AIESEC.

Education

  • Ph.D., Biotechnology (2021 - 2024) – SRM Institute of Science and Technology, Chennai, INDIA

  • M. Sc., Biotechnology (2018 -2020) – SRM Institute of Science and Technology, Chennai, INDIA

  • B.Sc., Biotechnology (2015 - 2018) – SRM Institute of Science and Technology, Chennai, INDIA

Key research areas

  • Toxicology, Pharmacology, Small molecules, Zebrafish disease modelling

Recent Publications

  1. Sudhakaran, G., Priya, P. S., Haridevamuthu, B., Murugan, R., Kannan, J., Almutairi, M. H., Almutairi, B. O., Guru, A., & Arockiaraj, J. (2024). Mechanistic interplay of dual environmental stressors: Bisphenol-A and cadmium-induced ovarian follicular damage and hepatocyte dysfunction in vivo. Science of The Total Environment, 171706. https://doi.org/10.1016/j.scitotenv.2024.171706 (IF-9.8)

  2. G. Sudhakaran, S.R. Babu, H. Mahendra, J. Arockiaraj, Updated experimental cellular models to study polycystic ovarian syndrome, Life Sci. 322 (2023) 121672. https://doi.org/10.1016/j.lfs.2023.121672 (IF-6.7)

  3. G. Sudhakaran, A. Guru, B. Hari Deva Muthu, R. Murugan, A. Arshad, J. Arockiaraj, Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian PCOS model, Life Sci. 291 (2022) 120276. https://doi.org/10.1016/j.lfs.2021.120276 (IF-6.7)

  4. G. Sudhakaran, A. Chandran, A.R. Sreekutty, S. Madesh, R. Pachaiappan, B.O. Almutairi, S. Arokiyaraj, Z.A. Kari, G. Tellez-Isaias, A. Guru, J. Arockiaraj, Ophthalmic Intervention of Naringenin Decreases Vascular Endothelial Growth Factor by Counteracting Oxidative Stress and Cellular Damage in In Vivo Zebrafish, Molecules. 28 (2023) 5350. https://doi.org/10.3390/molecules28145350. (IF-4.5)

  5. G. Sudhakaran, R. Rajesh, R. Murugan, M. Velayutham, A. Guru, S. Boopathi, S. Muthupandian, P. Gopinath, J. Arockiaraj, Nimbin analog N2 alleviates high testosterone induced oxidative stress in CHO cells and alters the expression of Tox3 and Dennd1a signal transduction pathway involved in the PCOS zebrafish, Phyther. Res. 37 (2023) 1449–1461 (IF-7.2)

  6. G. Sudhakaran, R. Rajesh, A. Guru, B. Haridevamuthu, R. Murugan, N. Bhuvanesh, M. Ahmad, S. Mahboob, A. Juliet, P. Gopinath, J. Arockiaraj, Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β -cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase ( PEPCK ) and insulin levels, Toxicol. Appl. Pharmacol. 454 (2022) 116229. https://doi.org/10.1016/j.taap.2022.116229 (IF-4.4)

  7. Sudhakaran, G., Priya, P. S., Jagan, K., Haridevamuthu, B., Meenatchi, R., & Arockiaraj, J. (2023). Osteoporosis in polycystic ovary syndrome (PCOS) and involved mechanisms. Life Sciences, 335(September), 122280. https://doi.org/10.1016/j.lfs.2023.122280 (IF-6.7)