Metabolic disorders  

Biography

Dr. P. Monisha is a dynamic researcher with a robust academic background and a passion for contributing to the field of Medical Biochemistry. With a Ph.D. in Medical Biochemistry, complemented by an M.Phil. and M.Sc. in Biochemistry, alongside a B.Sc. with distinction, Dr. Monisha brings a wealth of knowledge and expertise to any research endeavor. Her research contributions are highlighted by numerous publications in impactful journals, cumulatively achieving an impressive impact factor of 65.6. Her work encompasses diverse areas such as epigenetics, diabetes-related studies, and molecular biology, demonstrating her versatility and proficiency in various methodologies and techniques. Dr. Monisha has excelled in both academic and professional settings, demonstrating leadership as a Senior Research Fellow in government-funded projects and as an educator in esteemed institutions. Her experience includes in-depth exploration of high-fat diet-induced epigenetic changes in diabetic rats and the therapeutic potential of beta-sitosterol. Proficient in animal handling, molecular techniques, epigenetic methods, and bioinformatics, she is committed to continuous learning and advancing technical skills. Beyond her research prowess, Dr. Monisha is an active participant in workshops, seminars, and training sessions, reflecting her dedication to staying abreast of advancements in her field. Her commitment to scholarly pursuits is further evidenced by her engagement in online training programs and internships, including clinical research and pharmacovigilance. Throughout her career, Dr. Monisha has been recognized for her achievements, including prestigious awards for her poster presentations and publications. Her extensive involvement in academic and research roles at various institutions underscores her dedication to nurturing young minds and fostering a culture of scientific inquiry. Dr. P. Monisha is a driven and accomplished researcher poised to make significant contributions to the scientific community.

Education

  • Ph.D. in Medical Biochemistry - Saveetha Institute of Medical and Technical Sciences, Chennai - 2023

  • M.Phil in Biochemistry - Annamalai University, Annamalai Nagar - 2012

  • M.Sc. in Biochemistry - Avinashilingam University for Women, Coimbatore - 2010

  • B.Sc. in Biochemistry - Auxilium College, Vellore - 2008

Key research areas

  • Studying the impact of dietary factors on the onset and progression of metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases

  • Diabetes-related studies focusing on understanding the molecular mechanisms underlying insulin resistance and glucose metabolism dysregulation.

  • Epigenetics and its role in regulating gene expression and disease development, particularly in cancer.

  • Cell Culture techniques for studying cellular behavior, including animal cell lines and primary cultures, with a particular emphasis on cancer research and drug discovery.

  • Molecular Biology techniques for studying gene expression, DNA replication, and protein synthesis in cancer and animal models.

  • Bioinformatics analysis to interpret genomic and epigenomic data, including sequence alignment, motif prediction, and pathway analysis related to cancer biology and animal studies.

Recent Publications

  1. Monisha Prasad, Selvaraj Jayaraman, Sathan Raj Natarajan, Vishnu Priya Veeraraghavan, Rajapandiyan Krishnamoorthy, Mansour K Gatasheh, Chella Perumal Palanisamy, Mohamed Elrobh.  Piperine modulates IR/Akt/GLUT4 pathways to mitigate insulin resistance: Evidence from animal and computational studies. Int J Biol Macromol. 2023 Oct 4;253(Pt 5):127242. doi: 10.1016/j.ijbiomac.2023.127242. Epub ahead of print. PMID: 37797864 (IF-8.2)

  2. Monisha Prasad, Mansour K. Gatasheh, Mohammad A. Alshuniaber, Rajapandiyan Krishnamoorthy, Ponnulakhmi Rajagopal, Kalaiselvi Krishnamoorthy, Vijayalakshmi Periyasamy, Vishnu Priya Veeraraghavan and Selvaraj Jayaraman. Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NFκB Signalling Pathways. Antioxidants (Basel). 2022 Dec 9;11(12):2436. doi: 10.3390/antiox11122436. PMID: 36552644; PMCID: PMC9774325 (IF-7).

  3. Monisha Prasad, Vishnu Priya Veeraraghavan Selvaraj Jayaraman. Methylated ZNF582: a therapeutic target in oral cancer. Epigenomics. 2022 Nov;14(22):1389-1392. doi: 10.2217/epi-2022-0368. Epub 2023 Feb 1. PMID: 36722134 (IF-3.8).

  4. Monisha Prasad, Selvaraj Jayaraman, Ponnulakhmi Rajagopal, Vishnu Priya Veeraraghavan. Apoptosis regulating CircRNAs: Emerging role in oral cancer therapeutics. Oral Oncol. 2022 Nov; 134:106107. doi: 10.1016/j.oraloncology.2022.106107. Epub 2022 Sep 12. PMID: 36096046 (IF-4.8).

  5. Monisha Prasad, Vishnu Priya Veeraraghavan Selvaraj Jayaraman. Tumorigenic potential of GLUT4: A therapeutic target for head and neck squamous cell carcinoma. Oral Oncol. 2022 Oct; 133:106061. doi: 10.1016/j.oraloncology.2022.106061. Epub 2022 Aug 8. PMID: 35952585 (IF-4.8).

  6. Monisha Prasad, Selvaraj Jayaraman, Vishnu Priya Veeraraghavan.  An intriguing role of circular RNA in insulin resistance and endothelial dysfunction: the future perspectives. Hypertens Res. 2022 Nov;45(11):1843-1845. doi: 10.1038/s41440-022-01006-y. Epub 2022 Aug 26. PMID: 36028625 (IF-5.4).

  7. Monisha Prasad, Ponnulakshmi Rajagopal, Nalini Devarajan, Vishnu Priya Veeraraghavan, Chella Perumal Palanisamy, Bo Cui, Shankargouda Patil, Selvaraj Jayaraman, A comprehensive review on high -fat diet-induced diabetes mellitus: an epigenetic view. J Nutr Biochem. 2022 May 6; 107:109037. doi: 10.1016/j.jnutbio.2022.109037. Epub ahead of print. PMID: 35533900. (IF-5.6)

  8. Monisha Prasad, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Praveen Kumar Kumar, Shanmughavel Piramanayagam, Leelavinothan Pari. Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach. Chem Biol Interact. 2022 May 1; 358:109885. doi: 10.1016/j.cbi.2022.109885. Epub 2022 Mar 16. PMID: 35305976. (IF-5.1)

  9. Monisha Prasad, Selvaraj Jayaraman, Mohamed Ahmed Eladl, Mohamed El-Sherbiny, Mosaab Abdella Ebrahim Abdelrahman, Vishnu Priya Veeraraghavan, Srinivasan Vengadassalapathy, Vidhya Rekha Umapathy, Shazia Fathima Jaffer Hussain, Kalaiselvi Krishnamoorthy, Durairaj Sekar, Chella Perumal Palanisamy, Surapaneni Krishna Mohan, Ponnulakshmi Rajagopal, A Comprehensive Review on Therapeutic Perspectives of Phytosterols in Insulin Resistance: A Mechanistic Approach. Molecules. 2022 Feb 28;27(5):1595. doi: 10.3390/molecules27051595. PMID: 35268696; PMCID: PMC8911698. (IF-4.92)

  10. Selvaraj Jayaraman, Kalaiselvi Krishnamoorthy, Monisha Prasad, Vishnu Priya Veeraraghavan, Rajapandiyan Krishnamoorthy, Mohammad A Alshuniaber, Mansour K Gatasheh, Mohamed Elrobh , Gunassekaran (2023). Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1/PI3K/Akt mediated mechanisms: An in vivo and in silico analysis. International journal of biological macromolecules, 242 (Pt2), 124917. Advance online publication. https://doi.org/10.1016/j.ijbiomac.2023.124917 (IF- 8.2)