Small Molecules Drug Research

Biography

Dr. Vinod Kumar Nelson, obtained his MS. Pharm. in Natural Products from National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, West Bengal, India. Later, he earned his Ph.D. degree in Pharmaceutical Sciences from Bose Institute and Jadavpur University, Kolkata. He has almost 6 years of teaching & research experience. He is currently working as an associate professor in the department of Center for Global Health Research at Saveetha Institute of Medical and Technical Sciences (SIMATS). He has published papers in various reputed international journals like Aging Research Reviews, Food and Chemical toxicology, Journal of ethnopharmacology, Oncotarget, Molecular Neurobiology, BMC complementary medicine and therapies in the area of Natural Products in drug discovery. His area of interest in research focus on isolating small molecules from medicinal plants sources that modulate various transcription factors like Heat shock factor 1 (HSF1), Nuclear Factor Kappa-B (NF-κB), mTOR that helps in treating the dreadful diseases like cancer and Neurogenerative diseases by using cell as well as animal models.

Education

  • Ph.D., Pharmaceutical Sciences at Bose Institute and Jadavpur University, Kolkata. 

  • MS. Pharm. in Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Kolkata. 

Key research areas

  • Screening medicinal plants and isolating small molecule modulators of transcription factors that are associated with diseases like cancer and neurodegenerative diseases

  • Developing safe plant or herb-based formulations for the diseases like cancer and neurodegenerative diseases

Recent Publications

  1. Vinod Kumar Nelson, Mohana Vamsi Nuli, Saijyothi Ausali, Saurabh Gupta, Vaishnavi Sanga, Richa Mishra, Pavan kumar Jaini, Sudha Divya Madhuri Kallam, Hari Hara Sudhan, Vinyas Mayasa. Dietary Anti-inflammatory and Anti-bacterial medicinal Plants and its compounds in Bovine mastitis associated impact on human life: A Comprehensive Review. Microbial Pathogenesis. doi: 10.1016/j.micpath.2024.106687.  

  2. Payal Chauhan; Karan Wadhwa; Govind Singh; Danish Iqbal, Mohana Vamsi Nuli; Mosleh Mohammad Abomughaid, Vinod Kumar Nelson; Niraj Kumar Jha. Investigating the potential therapeutic mechanisms of Puerarin in Neurological Diseases. Molecular Neurobiology, Springer. 10.1007/s12035-024-04222-4.

  3. Vinod Kumar Nelson, Niraj Kumar Jha, Mohana Vamsi Nuli, Sandeep Kanna, Reema M Gahtani, Umme Hani, Arun Kumar Singh, Saurabh Gupta, Mosleh Mohammad Abomughaid, Ali M Abomughayedh,.Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications. Ageing Research Reviews. 10.1016/j.arr.2024.102224.

  4. Punya Sachdeva, Kannan Badri Narayanan, Jitendra Kumar Sinha, Arockia Babu, Shampa Ghosh, Rakesh Bhaskar, Vinod Kumar Nelson, a. Recent Advances in Drug Delivery Systems Targeting Insulin Signalling for the Treatment of Alzheimer's Disease. Journal of Alzheimer’s disease. 10.3233/JAD-231181.

  5. M. Alagusundaram, Nem Kumar Jain, M. Yasmin Begum, S. Angala Parameswari, Vinod Kumar Nelson, Mohammad F. Bayan and Balakumar Chandrasekaran  Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine. (MDPI- gels). 10.3390/gels9090688. 

  6. Mazin Aboobaida Abdalla Abdelaziz, Vinod Kumar Nelson, Murali Kumarasamy, Ramalingam Peraman. Anticancer effect of polyphenolic acid enriched fractions from Grewia bracteata Roth on tumor cells and their p53 gene independent ROS mediated apoptosis in colon cancer cells. Toxicon. 10.1016/j.toxicon.2023.107243.  

  7. Vinod K Nelson, Mohana vamsi Nuli, Juturu Mastanaiah, Mohamed Saleem T.S, Geetha Birudala, Yahya . Jamous, Shubhadeep Roychoudhury. Reactive Oxygen Species Mediated Apoptosis and Colon Cancer Cell death: Therapeutic approach with Plant derived alkaloids: A critical review. Frontiers in Endocrinology. 10.3389/fendo.2023.1201198.   

  8. Samhita De, Sourav Paul, Anirban Manna, Chirantan Majumder, Koustav Pal, Nicolette Casarcia, Arijit Mondal, Sabyasachi Banerjee, Vinod Kumar Nelson, Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies. Cancer (MDPI). 10.3390/cancers15030993.

  9. Sreelakshmi Badavenkatappa gari, Vinod K Nelson, and Ramalingam Peraman Tinospora sinensis (Lour.) Merr Alkaloid rich extract induces colon cancer cell death via   ROS mediated, mTOR dependent apoptosis pathway: “An in-vitro study. BMC Complementary medicine and therapies. 10.1186/s12906-023-03849-5.

  10. Naibedya Dutta, Deepak Pemmaraju, Suvranil Ghosh, Asif Ali, Ayan Mandal, Chirantan Majumder, Vinod K Nelson, Subhash C Mandal, Anup K Misra, Aravind K Rengan, Velyutham Ravichandiran. Alkaloid-rich fraction of Ervatamia coronaria sensitizes colorectal cancer through modulating AMPK and mTOR signalling pathways. Journal of Ethanopharmacology. 10.1016/j.jep.2021.114666.