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Molecular Biochemistry

Biography

Dr. Parameswari, Associate Professor at the Centre for Global Health Research, Saveetha Medical College and Hospitals, brings an illustrious academic background and rich research experience spanning over 15 years. She earned her Masters from the University of Madras, followed by her Doctorate from the prestigious Sri Ramachandra Medical College and Research Institute. Her professional trajectory commenced as a junior research fellow at Sri Ramachandra University, where she devoted 13 years to various central government-funded projects. Her tenure at Sri Ramachandra University was marked by exceptional dedication and significant contributions to multiple research endeavours. She has been honoured twice with the International Conference Fellowship by the Alzheimer’s Association, USA, a testament to her impactful work in the field. Her research prowess has also been acknowledged with meritorious research publication awards and the prestigious SERB travel grant in 2022. With a keen focus on innovation, Dr. Parameswari has filed four IPR patents. She has more than 40 Publications for her credit with cumulative impactor factor above 130. Her research concentrates on the intersection of metabolic disorders and neurodegenerative diseases, aiming to unravel the intricate crosstalk between these conditions. Her current endeavours involve establishing sophisticated in vitro co-culture models using diabetic and neuronal cell lines. This cutting-edge research holds promise for understanding the complexities of these disorders and exploring potential therapeutic avenues.

Education

  • Ph.D Biochemistry – Sri Ramachandra Institute of Higher Education and Research – 2018.

  • M.Phil Biochemistry – Annamalai University – 2007 – 2008.

  • M.Sc Biochemistry - University of Madras – 2003 – 2005.

  • B.Sc Chemistry - Ethiraj college for Women – 2000 – 2003.

Key research areas

  • Sleep disorders

  • Metabolic disorders

  • Neurodegenerative disease

  • Neuropharmacology

  • Natural Products Research

Recent Publications

  1. Visallini T and Parameswari, R.P., Retrospective case study on the evaluation of inflammatory markers, Macrophage Inhibitory Protein-1⍺ and Interferon- γ in sleep deprivation condition. Journal of Pharmacy and BioAllied Health Sciences. 2024. (IF – 0.8).

  2. Computational Exploration of FOXM1 Inhibitors for Glioblastoma: An Integrated Virtual Screening and Molecular Dynamics Simulation Study. Journal of Biomolecular Structure and Dynamics. 2024. https://doi.org/10.1080/07391102.2024.2308772. (IF – 4.4)

  3. Parameswari, R.P., Varshan I, Shanmugam R. In Vitro Anti-diabetic Activity of Pomegranate Peel Extract-Mediated Strontium Nanoparticles. Cureus. 2023 Dec 30;15(12).

  4. Nair, V.R., Geetha, R.V., Parameswari, R.P. Aldose Reductase and Protein Glycation Inhibitory Activity of Dark Chocolate-Assisted Zinc Oxide Nanoparticles. Cureus. 2023 Nov 17;15(11).

  5. Danish, M., Al-Amin, M., Rubaiee, S., Parameswari, R.P., Abdul-Rani, A.M., Ahmed, A. and Yildirim, M.B., 2023. Investigation of coated 316L steel surface employing carbon nanotubes mixed-electrical discharge machining for biomedical applications. Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering, p.09544089231175058. (IF – 2.3)

  6. S.Jeswin Immanuel, Parameswari R.P., Lakshmi Thangavelu, Antiproliferative and apoptotic effect of herbal formulation containing black and green tea extract against HCT-116 human colon cancer cells. Journal of Population Therapeutics and Clinical Pharmacology, DOI: 10.47750/jptcp.2023.30.16.047.

  7. Rajeshkumar, S., Parameswari, R.P., Sandhiya, D., Al-Ghanim, K.A., Nicoletti, M. and Govindarajan, M., 2023. Green Synthesis, Characterization and Bioactivity of Mangifera indica Seed-Wrapped Zinc Oxide Nanoparticles. Molecules, 28(6), p.2818. (IF – 4.9)

  8. Parameswari RP, Ramesh G, Chidambaram SB, Thangavelu L. Oxidative stress mediated neuroinflammation induced by chronic sleep restriction as triggers for Alzheimer’s disease. Alzheimer's & Dementia. 2022 Dec;18:e059016. (IF – 16.65)

  9. Parameswari RP. Merkel cell carcinoma-Time to consider personalized medicine and combinatorial therapeutic strategies. Oral oncology. 2022 Nov 1:106220. (IF – 5.97)

  10. Parameswari.R.P., Lakshmi Thangavelu. Microalgae as a potential therapeutic drug candidate for neurodegenerative diseases. Journal of Biotechnology. Available online 16 September 2022. (IF – 3.59)